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What is acid rebound effect? PPI use is known to cause acid rebound, and the effect is thought to be related to PPI -induced gastrin secretion (secondary to an increase in gastric pH) and to gastrin's effect on parietal cell mass expansion, which leads to increased acid secretion.
How long do ppi stay in system? Half-lives vary with each PPI. Esomeprazole (Nexium) and omeprazole (Prilosec) have the longest half-lives at almost three hours, and lansoprazole (Prevacid), dexlansoprazole (Dexilant), pantoprazole (Protonix) and rabeprazole (Aciphex) have shorter half-lives at about one to two hours.
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