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The most common side effects you may experience in the first few weeks of taking HRT are a feeling of sickness (nausea), some breast discomfort or leg cramps. These tend to go within a few months if you continue to take HRT. Some women find that certain makes of HRT skin patches cause irritation of their skin.
Is transdermal HRT safer than oral?
Compared with transdermal treatment, the use of oral hormone replacement therapy (HRT) is associated with a greater risk of venous thromboembolism (VTE), according to a retrospective database study. " HRT treatment involves a whole class of drugs and some are safer than others.
What symptoms does estradiol help?
What Is Estradiol and How Does It Work? Estradiol is a female hormone (estrogen). It is used by women to help reduce vaginal symptoms of menopause (such as vaginal dryness/burning/itching). Tablet. Vulvar and Vaginal Atrophy in Menopause. Vasomotor Symptoms Associated with Menopause. Prostate Cancer.